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ARN19702 is a selective, orally active, reversible, brain-penetrant inhibitor of N-acylethanolamine acid amidase (NAAA) with an IC50 of 230 nM against human NAAA. It has demonstrated analgesic effects in preclinical models and is supplied at high purity for use as a biochemical tool compound in NAAA-related research.
Selective N-acylethanolamine acid amidase (NAAA) inhibition for targeted pathway studies.
Orally active and brain-penetrant properties enable central nervous system investigations.
Reversible mechanism suitable for transient modulation of enzyme activity.
Potent activity (IC50 230 nM) for use in cellular and in vivo assays.
High purity for reliable biochemical and pharmacological experiments.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
YQ128 is a potent, selective, second-generation small-molecule inhibitor of the NLRP3 inflammasome intended for research use. It inhibits NLRP3-mediated IL-1β production (reported IC50 ~0.30 μM), exhibits anti-inflammatory activity, and is reported to cross the blood-brain barrier. The molecule contains an alkyne functional group enabling copper-catalyzed azide-alkyne cycloaddition for conjugation applications.